The physicochemical properties of membranes correlate with the NADPH oxidase activity

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• 作者：Hager Souabni^a ; ¹ ; Frank Wien^b ; Tania Bizouarn^a ; Chantal Houé ; e-Levin^a ; Matthieu Ré ; fré ; giers^b ; Laura Baciou^a ; ^{laura.baciou@u-psud.fr}
• 关键词：rCytb558 ; recombinant cytochrome b558 ; ER ; membrane of endoplasmic reticulum ; PM ; plasma membrane ; PL ; proteoliposome ; AA ; arachidonic acid ; DMSO ; dimethylsulphoxide ; SOD ; superoxide dismutase ; Nox ; NADPH oxidase ; Cytc ; cytochrome c ; PMSF ; phenylmethanesulfonyl fluoride ; MβCD ; methyl-β-cyclodextrin ; DDM ; n-dodecyl β-d-maltoside ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; DMPC ; 1 ; 2-dimyristoyl-sn-glycero-3-phosphocholine ; Ea ; Arrhenius activation energy ; NADPH ; reduced β-nicotinamide adenine
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3520-3530
• 全文大小：1638 K
• 卷排序：1861

文摘

High temperatures promote high production rates of superoxide anions. Production of reactive oxygen species is closely related to bilayer composition and membrane thickness. Oxidase activation energy is correlated to the bilayer fluidity. Sterols are negative regulators of NADPH oxidase activity.