Use of a current varicella vaccine as a live polyvalent vaccine vector

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• 作者：Kouki Murakami^a ; ^b ; Yasuko Mori^a ; ^{ymori@med.kobe-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Varicella vaccine ; Oka strain ; Live polyvalent vaccine
• 刊名：Vaccine
• 出版年：2016
• 出版时间：4 January 2016
• 年：2016
• 卷：34
• 期：2
• 页码：296-298
• 全文大小：816 K

文摘

Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The varicella vaccine was developed to control VZV infection in children. The currently available Oka vaccine strain is the only live varicella vaccine approved by the World Health Organization. We previously cloned the complete genome of the Oka vaccine strain into a bacterial artificial chromosome vector and then successfully reconstituted the virus. We then used this system to generate a recombinant Oka vaccine virus expressing mumps virus gene(s). The new recombinant vaccine may be an effective polyvalent live vaccine that provides protection against both varicella and mumps viruses. In this review, we discussed about possibility of polyvalent live vaccine(s) using varicella vaccine based on our recent studies.