Carrier systems for bacteriophages to supplement food systems: Encapsulation and controlled release to modulate the human gut microbiota
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- 作者：Meike Samtlebea ; meike.samtlebe@uni-hohenheim.de" class="auth_mail" title="E-mail the corresponding author ; Firuze Erginb ; Natalia Wagnerc ; Horst Nevec ; Ahmet Kü ; ç ; ü ; kç ; etinb ; Charles M.A.P. Franzc ; Knut J. Hellerc ; Jö ; rg Hinrichsa ; Zeynep Atamera
- 关键词：Gut microbiota ; Encapsulation ; Bacteriophage ; Gastric acid ; In vitro release
- 刊名：LWT - Food Science and Technology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：334-340
- 全文大小：1175 K
文摘
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Methods to encapsulate Lactococcus lactis phage P008 were tested and optimized.
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Sensitivity of encapsulated phage and free phage to acid conditions was analyzed.
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Release of phage from the capsules by exposure to intestinal fluid was determined.
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The encapsulation improved the survival of phage under acidic conditions at pH 2.
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Phage release up to 90% after incubation in intestinal fluid was observed.