Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages

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• 作者：Eui-Baek Byun^a ; ^b ; Beom-Su Jang^a ; ^b ; Hye-Min Kim^a ; ^d ; Mi-So Yang^c ; Nak-Yun Sung^d ; Eui-Hong Byun^d ; ^{ehbyun80@kongju.ac.kr}
• 关键词：HPLC ; high-performance liquid chromatography ; HRP ; horseradish peroxidase ; LPS ; lipopolysaccharide ; Tollip ; toll-interacting protein ; TLR ; toll-like receptor ; MHC ; major histocompatibility complex ; NF-κB ; nuclear factor-κB ; IκB ; inhibitor of κB ; TNF-α ; tumor necrosis factor-α ; IL ; interleukin ; MAPK ; mitogen-activated protein kinase ; COX ; cyclooxygenase ; iNOS ; nitric oxide synthase ; NO ; nitric oxide ; ELISA ; enzyme-linked immunosorbent assay ; PGE2 ; prostaglandin E2 ; ROS ; reactive oxygen species ; S
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：157-167
• 全文大小：1601 K
• 卷排序：42

文摘

Gamma-irradiation induced structural modification of quercetin. Gamma-irradiated quercetin inhibited the pro-inflammatory mediators. Gamma-irradiated quercetin induced an inhibition of MAPKs and NF-κB. Gamma-irradiated quercetin enhanced Tollip-mediated anti-inflammation.