Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation
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- 作者：Diego Balboa1 ; 4 ; Jere Weltner1 ; 4 ; Solja Eurola1 ; Ras Trokovic1 ; Kirmo Wartiovaara1 ; 3 ; Timo Otonkoski1 ; 2 ; timo.otonkoski@helsinki.fi" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：5
- 期：3
- 页码：448-459
- 全文大小：4318 K
文摘
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dCas9VP192 targeted to proximal promoters activates transcription in different loci
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Transgenic OCT4 can be replaced by dCas9VP192
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Destabilized dCas9VP192 enables temporal control of gene expression by TMP
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TMP and DOX can be combined to control multiple genes in differentiation