Sensitive and label-free quantification of cellular biothiols by competitive surface-enhanced Raman spectroscopy
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- 作者：Jingjing Zhao ; Kun Zhang ; Ji Ji ; Baohong Liu ; bhliu@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Competitive adsorption ; Plasmonic switching ; SERS ; Biological thiols ; Optical detection
- 刊名：Talanta
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：196-202
- 全文大小：2132 K
文摘
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A competitive and lable-free SERS sensor is developed for rapid detection of biothiols.
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The method shows much improved sensitivity with LOD down to picomolar levels.
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This protocol is facile involving neither pre-concentration nor signal amplification.
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The method is reliable and can be applied to directly detect cellular biothiols.