Pharmacological study of a cannabinoid-containing eyedrop formulation in dogs and mice
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- 作者：Aline Maria Stolfa ; Daiana Lugarinia ; Anabel de Oliveiraa ; Adriana Pastre Serenikia ; b ; Caroline Santos Capitellia ; Douglas Hideki Tanakac ; Fabiano Montiani Ferreirac ; Maria Aparecida Barbato Frazã ; o Vitala ; Alexandra Accoa ; aleacco@ufpr.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：CB1 ; cannabinoid receptor type 1 ; CB2 ; cannabinoid receptor type 2 ; CBD ; cannabidiol ; EPM ; elevated plus maze ; GABA ; gamma aminobutyric acid ; GPR55 ; G protein-coupled receptor 55 ; HT ; open field habituation test ; IOP ; intraocular pressure ; i.p. ; intraperitoneal ; MBT ; marble burying test ; Oc ; ocular ; OF ; open field ; PD ; pupillary diameter ; PM ; plus maze ; THC ; tetrahydrocannabinol ; TRPV1 ; transient receptor potential cation channel subfamily V member 1
- 刊名：Journal of Applied Biomedicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：14
- 期：1
- 页码：41-48
- 全文大小：928 K
文摘
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The cannabinoid-containing eyedrop reduced the intraocular pressure in healthy dogs.
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The cannabinoid-containing eyedrop has potential for the treatment of glaucoma in dogs.
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The cannabinoid-containing eyedrop induced psychotropic effects in mice only upon systemic administration.