Total Synthesis of (+)-Zaragozic Acid C

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• 作者：Armstrong ; Alan ; Jones ; Lyn H. ; Barsanti ; Paul A.
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：May 14, 1998
• 年：1998
• 卷：39
• 期：20
• 页码：3337-3340
• 全文大小：260 K

文摘

A total synthesis of (+)-zaragozic acid C is described. Key steps are an acid-mediated acetonide deprotection-dithiane removal-ketalisation procedure, providing selectively the 2,8-dioxabicyclo[3.2.1]octane core of the natural product, and the simultaneous introduction of the C3, C4 and C5 carboxylic acids via triple oxidation.