Cholinergic agonist reverses H1-induced memory deficit in mice
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- 作者：C.E.M. Fernandes ceduardomonici@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; K.R. Serafim kelly.serafim@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; A.C.L. Gianlorenç ; o acgianlorenco@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; R. Mattioli ; mattioli@ufscar.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：HA ; histamine ; HNS ; histaminergic neural system ; ACh ; acetylcholine ; EPM ; elevated plus maze ; CPA ; chlorpheniramine maleate ; SAL ; saline ; T1 ; Trial 1 ; T2 ; Trial 2 ; %OAE ; percentage of open arm entries ; %OAT ; percentage of open arm time ; OAE ; open arm entries ; EAE ; enclosed arm entries ; OAT ; open arm time ; EAT ; enclosed arm time ; TE ; total arm entries ; CT ; central area time ; NBM ; nucleus basalis magnocellularis ; BLA ; basolateral complex of the amygdala ; IA ; inhibitory avoidance
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2017
- 出版时间：4 January 2017
- 年：2017
- 卷：72
- 期：Complete
- 页码：16-22
- 全文大小：972 K
文摘
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Chlorpheniramine and PNU-282987 did not induce effects on anxiety in elevated plus maze.
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The PNU-282987 per se did not produce effects on emotional memory.
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Microinjections of PNU-282987 reverse memory deficits induced by chlorpheniramine.