Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)
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- 作者：Jonathan M. Van Dyke ; Ivy M. Smit-Oistad ; Corey Macrander ; Dan Krakora ; Michael G. Meyer ; Masatoshi Suzuki ; masatoshi.suzuki@wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-BTX ; alpha-bungarotoxin ; AChR ; acetylcholine receptor ; ALS ; amyotrophic lateral sclerosis ; ANOVA ; analysis of variance ; BBB ; Basso&ndash ; Beattie&ndash ; Bresnahan hindlimb locomotor rating ; BVC ; bupivacaine hydrochloride ; CD11b ; cluster of differentiation 11b ; CD68 ; cluster of differentiation 68 ; C9ORF72 ; chromosome 9 open reading frame 72 ; EDTA ; Ethylenediaminetetraacetic acid ; EGTA ; ethylene glycol tetraacetic acid ; ELISA ; enzyme-linked immunosorbent assay ; GAPDH ; Glyceraldehyde-3-phosphate de
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：275-282
- 全文大小：1125 K
文摘
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Macrophage-mediated inflammation is increased at the NMJs in ALS rats following disease progression.
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Strong expressions of reactive glial markers are observed near NMJs.
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TSCs dissociate when NMJ integrity is lost.
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Ex vivo GDNF delivery alters inflammation and maintains TSC-NMJ association.