Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats
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- 作者：Bo Fang drunk0630@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiao-Qian Li shirley037305@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Na-Ren Bao bnrlzh@sina.com" class="auth_mail" title="E-mail the corresponding author ; Wen-Fei Tan winfieldtan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Feng-Shou Chen haoxiu19881988@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiao-Li Pi cmupxl@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ying Zhang wojiaotielihua@126.com" class="auth_mail" title="E-mail the corresponding author ; Hong Ma ; mahong5466@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-MA ; 3-methyladenine ; Bax ; Bcl-2-associated X protein ; BBB ; Basso&ndash ; Beattie&ndash ; Bresnahan ; Bcl-2 ; B-cell lymphoma-2 ; CD31 ; platelet endothelial cell adhesion molecule-1 ; ELISA ; enzyme-linked immunosorbent assay ; GFAP ; glial fibrillary acidic protein ; I/R ; ischemia reperfusion ; Iba-1 ; ionized calcium-binding adaptor molecule 1 ; IL-1β ; interleukin-1β ; LC3 ; microtubule-associated protein light chain 3 ; NeuN ; neuronal nuclei ; PBS ; Phosphate-buffered saline ; TNF-α ; tumor necrosis factor-α ; TUN
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：328
- 期：Complete
- 页码：107-116
- 全文大小：2396 K
文摘
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Autophagy was upregulated after spinal cord ischemia reperfusion injury.
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Early activated autophagy alleviates spinal cord ischemia reperfusion injury via inhibiting apoptosis and inflammation.
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Later excessive elevated autophagy aggravates ischemia reperfusion injury through inducing autophagic cell death.