Serotonin 2A receptor (5-HT2A) gene promoter variant interacts with chronic perceived stress to modulate resting parasympathetic activity in humans

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• 作者：Chuan-Chia Chang^a ; ^b ; ^{changcc@ndmctsgh.edu.tw} ; Wen-Hui Fang^c ; Hsin-An Chang^a ; Tieh-Ching Chang^a ; Jia-Fwa Shyu^a ; ^d ; San-Yuan Huang^a ; ^b
• 关键词：5-HT2A ; serotonin 2A receptor ; ANS ; autonomic nervous system ; BAI ; Beck Anxiety Inventory ; BDI ; Beck Depression Inventory-II ; BMI ; body mass index ; CVDs ; cardiovascular diseases ; DBP ; diastolic blood pressure ; ECG ; electrocardiogram ; HF ; high frequency power ; HR ; heart rate ; HRV ; heart rate variability ; LF ; low frequency power ; LF/HF ; ratio of LF to HF ; PSS ; Perceived Stress Scale ; RMSSD ; root mean square of successive heartbeat interval differences ; SBP ; systolic blood pressure ; SNP ; single nuc
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：119-126
• 全文大小：906 K
• 卷排序：76

文摘

The 5-HT2A rs6311 variant interacts with chronic perceived stress to affect resting vagal tone. Carriers of the T/T genotype with sustained high perceived stress show lower resting vagal tone. However, no such effect was found in the subjects with chronically low levels of perceived stress.