Small Molecules Take A Big Step Against Clostridium difficile

详细信息    查看全文

• 作者：Greg L. Beilhartz¹ ; John Tam¹ ; Roman A. Melnyk¹ ; ² ; ^{roman.melnyk@sickkids.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Clostridium difficile ; TcdB ; small molecule ; ebselen ; inhibitor
• 刊名：Trends in Microbiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：23
• 期：12
• 页码：746-748
• 全文大小：543 K

文摘

Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al., using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a new modality in the fight against C. difficile.