Voltammetric investigation of Tamsulosin

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• 作者：&Ouml ; zkan ; Sibel A. ; Uslu ; Bengi ; Aboul-Enein ; Hassan Y.
• 关键词：Tamsulosin HCl ; Determination ; Modified release capsules ; Voltammetric methods
• 刊名：Talanta
• 出版年：2003
• 出版时间：October 17, 2003
• 年：2003
• 卷：61
• 期：2
• 页码：147-156
• 全文大小：260 K

文摘

The electrooxidative behavior and determination of Tamsulosin HCl (TAM), one of the α₁-adrenoceptor antagonist, on a glassy carbon disc electrode were investigated for the first time by using cyclic, linear sweep, differential pulse (DPV) and square wave voltammetry (SWV). TAM showed an irreversible oxidation behavior at all pH values and buffers studied. From the electrochemical response, the main oxidation step was found to be related to the methoxy group on the phenyl ring. DPV and SWV were used to generate peak current versus concentration curves for TAM. A linear response was obtained in the range comprised between 2×10⁻⁶ and 4×10⁻⁴ M for both techniques with detection limit of 3.34×10⁻⁷ M for DPV and 2.45×10⁻⁷ M for SWV. The methods were proposed for the determination of TAM in dosage forms adopting both DPV and SWV modes. The methods were extended to the in vitro determination of TAM in spiked serum samples.