Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML
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- 作者：Rishi V. Puram1 ; 2 ; 3 ; Monika S. Kowalczyk3 ; Carl G. de Boer3 ; Rebekka K. Schneider1 ; Peter G. Miller1 ; 4 ; Marie McConkey1 ; Zuzana Tothova1 ; 3 ; 4 ; Hé ; ctor Tejero5 ; Dirk Heckl1 ; 6 ; Marcus Jä ; rå ; s1 ; 7 ; Michelle C. Chen1 ; Hubo Li2 ; 4 ; Alfred Tamayo8 ; Glenn S. Cowley3 ; Orit Rozenblatt-Rosen3 ; Fatima Al-Shahrour1 ; 5 ; Aviv Regev3 ; 9 ; 10 ; Benjamin L. Ebert1 ; 3 ; 4 ; bebert@partners.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：165
- 期：2
- 页码：303-316
- 全文大小：3523 K
文摘
Normal and malignant hematopoietic cells harbor an intact circadian clock
Circadian rhythm genes Clock and Bmal1 are required for AML cell growth
Disruption of circadian rhythm machinery leads to leukemia stem cell differentiation
Genetic loss of Bmal1 impairs AML maintenance while sparing normal hematopoiesis