DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration

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• 作者：Jerome Irianto¹ ; ² ; Yuntao Xia¹ ; ² ; Charlotte R. Pfeifer¹ ; ² ; ³ ; Avathamsa Athirasala² ; Jiazheng Ji¹ ; ² ; Cory Alvey¹ ; ² ; Manu Tewari¹ ; ² ; Rachel R. Bennett¹ ; ³ ; Shane M. Harding¹ ; ⁴ ; Andrea J. Liu¹ ; ³ ; Roger A. Greenberg¹ ; ⁴ ; Dennis E. Discher¹ ; ² ; ³ ; ⁵ ; ^{discher@seas.upenn.edu}
• 关键词：motility ; migration ; lamina ; nuclear envelope ; rupture ; extracellular matrix ; DNA damage ; DNA repair ; copy number variation ; cancer
• 刊名：Current Biology
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：27
• 期：2
• 页码：210-223
• 全文大小：7242 K
• 卷排序：27

文摘

Constricted migration causes mis-localization of DNA repair proteins and DNA breaks Depletion of repair factors leads to DNA damage and chromosomal aberrations Migration of cancer clones through small pores causes lasting genomic heterogeneity Gene dosage effects in the transcriptome can perturb cell shape and motility