Benomyl-induced effects of ORMDL3 overexpression via oxidative stress in human bronchial epithelial cells

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• 作者：Yoonjeong Jang^a ; ¹ ; Ah Young Lee^a ; ¹ ; Ji-Eun Kim^a ; Sang-Hee Jeong^b ; Jun Sung Kim^c ; ^{lifeisgood@biterials.com} ; Myung-Haing Cho^a ; ^{mchotox@snu.ac.kr}
• 关键词：Benomyl ; ORMDL3 ; Reactive oxygen species ; Human bronchial epithelial cells
• 刊名：Food and Chemical Toxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：98
• 期：part_PB
• 页码：100-106
• 全文大小：1545 K
• 卷排序：98

文摘

Benomyl generates ROS in human bronchial epithelial cells 16HBE14o−. Benomyl upregulates asthma-related proteins, ADAM33 and ORMDL3. Antioxidants alleviate the effects of benomyl exposure in 16HBE14o− cells. Metalloproteinases and cytokines involved in asthma pathogenesis could be proposed as downstream pathways of ORMDL3 overexpression by benomyl.