用户名: 密码: 验证码:
Immunoglobulin M Monoclonal Gammopathy of Undetermined Significance and Smoldering Waldenstr?m Macroglobulinemia
详细信息    查看全文
文摘
| Figures/TablesFigures/Tables | ReferencesReferences

Abstract

Monoclonal gammopathy of undetermined significance of the immunoglobulin M class was diagnosed in 213 patients at the Mayo Clinic, 29 (14 % ) of whom developed lymphoma, Waldenstr?m macroglobulinemia, or a related disorder over 1567 person-years of follow-up. The cumulative probability of progression was 10 % at 5 years, 18 % at 10 years, and 24 % at 15 years, or approximately 1.5 % per year. The concentration of serum monoclonal protein at diagnosis and the initial serum albumin value were the only independent predictors of progression with multivariate analysis.

By contrast, during 285 person-years of follow-up, 34 (71 % ) of 48 patients with smoldering Waldenstr?m macroglobulinemia (SWM) progressed to Waldenstr?m macroglobulinemia (WM), which required therapy, along with amyloid light chain (AL) amyloidosis (1) and lymphoma (1). The cumulative probability of progression was 6 % at 1 year, 39 % at 3 years, 59 % at 5 years, and 65 % at 10 years. The percentage of lymphoplasmacytic cells in the bone marrow, size of the serum monoclonal (M) spike, and hemoglobin value were significant independent risk factors for progression.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700