Synthesis of unsymmetrical bis-heterocycles containing the imidazo[2,1-b]thiazole framework and their benzo[d]fused analogues by an acid-free Groebke-Blackburn-Bienaymé reaction
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- 作者：Kranthi G. Kishore ; Alejandro Islas-Já ; come ; Angel Renterí ; a-Gó ; mez ; Alain S. Conejo ; Unnamatla M.V. Basavanag ; Kazimierz Wrobel ; Rocí ; o Gá ; mez-Montañ ; o ; rociogm@ugto.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bis-heterocycles ; Imidazo[2 ; 1-b]thiazoles ; Benzo[d]imidazo[2 ; 1-b]thiazoles ; Groebke&ndash ; Blackburn&ndash ; Bienaymé ; reaction ; DFT-based calculations
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：3 August 2016
- 年：2016
- 卷：57
- 期：31
- 页码：3556-3560
- 全文大小：677 K
文摘
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GBBR works well in acid-free conditions.
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Imidazo[2,1-b]thiazoles and benzo[d]imidazo[2,1-b]thiazoles are synthesized using water as solvent.
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Acid-free GBBR mechanism involves a two-step instead of concerted pathway.