Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells
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- 作者：C. Huanga ; P. Yuanb ; J. Wua ; J. Huanga ; jianhuang@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; CNS ; central nervous system ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; E2 ; 17β-Estradiol ; EAAC1 ; excitatory amino acid carrier 1 ; EAATs ; excitatory amino acid transporters ; EREs ; estrogen response elements ; FCS ; charcoal-stripped fetal bovine serum ; FGF2 ; fibroblast growth factor 2 ; FGFR ; FGF receptor ; FRS2α ; FGFR substrate 2α ; G1 ; (± ; )-1-[(3aR&lowast ; 4S&lowast ; 9bS&lowast ; )-4-(6-bromo-1 ; 3-benzodioxol-5-yl)-3a ; 4 ; 5 ; 9b-tetrahydro-3H-cyclopenta[c]qu
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：319
- 期：Complete
- 页码：9-22
- 全文大小：2160 K
文摘
- 5">
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5">Estrogen (E2) induced EAAC1 expression with a resistance against H2O2 toxicity.
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E2 activated Sphk1 to evoke FGFR–ERK cascade and subsequent EAAC1 synthesis.
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5">GPR30 mediated the downstream events of E2 in regulating EAAC1 expression.
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This study may reveal new targets or drugs for diseases related to oxidative stress.