Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition

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• 作者：Shigeki Nakagawa¹ ; ² ; ²¹ ; Lan Wei³ ; ²¹ ; Won Min Song¹ ; ⁴ ; ²¹ ; Takaaki Higashi¹ ; ² ; Sarani Ghoshal³ ; Rosa S. Kim¹ ; C. Billie Bian¹ ; Suguru Yamada³ ; Xiaochen Sun¹ ; Anu Venkatesh¹ ; Nicolas Goossens¹ ; ⁵ ; Gretchen Bain⁶ ; Gregory Y. Lauwers⁷ ; Anna P. Koh¹ ; Mohamed El-Abtah¹ ; Noor B. Ahmad¹ ; Hiroki Hoshida¹ ; Derek J. Erstad³ ; Ganesh Gunasekaran⁸ ; Youngmin Lee¹ ; Ming-Lung Yu⁹ ; ¹⁰ ; Wan-Long Chuang⁹ ; Chia-Yen Dai⁹ ; Masahiro Kobayashi¹¹ ; Hiromitsu Kumada¹¹ ; Toru Beppu² ; Hideo Baba² ; Milind Mahajan⁴ ; Venugopalan D. Nair¹² ; Michael Lanuti¹³ ; Augusto Villanueva¹ ; Angelo Sangiovanni¹⁴ ; Massimo Iavarone¹⁴ ; Massimo Colombo¹⁴ ; Josep M. Llovet¹ ; ¹⁵ ; Aravind Subramanian¹⁶ ; Andrew M. Tager¹⁷ ; Scott L. Friedman¹ ; Thomas F. Baumert¹⁸ ; ¹⁹ ; ²⁰ ; Myron E. Schwarz⁸ ; Raymond T. Chung²⁰ ; Kenneth K. Tanabe³ ; Bin Zhang⁴ ; Bryan C. Fuchs³ ; ^{bfuchs@mgh.harvard.edu} ; Yujin Hoshida¹ ; ²² ; ^{yujin.hoshida@mssm.edu} ; on behalf of the Precision Liver Cancer Prevention Consortium
• 关键词：hepatocellular carcinoma ; cancer chemoprevention ; transcriptome ; gene signature ; prognostic prediction
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：12 December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：879-890
• 全文大小：4180 K
• 卷排序：30

文摘

Clinically applicable pan-etiology HCC risk biomarker was established Global transcriptome map of cirrhosis identified HCC chemoprevention targets Global transcriptome map of cirrhosis identified clinically relevant animal models LPA pathway inhibitors were verified as HCC chemopreventive and anti-fibrotic drugs