- 作者：Marí ; a Heredia-Rodrí ; guez ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>bsup> ; Juan Bustamante-Munguira ; M.D. ; Ph.D.<sup>csup><sup> ; sup><sup>jbustamantemunguira@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup><sup> ; sup><sup>bustamj@hotmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Inmaculada Fierro ; Ph.D.<sup>dsup> ; Mario Lorenzo ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>bsup> ; Pablo Jorge-Monjas ; M.D. ; Ph.D.<sup>bsup> ; Esther Gó ; mez-Sá ; nchez ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>bsup> ; Francisco J. Á ; lvarez ; M.D. ; Ph.D.<sup>csup> ; Sergio D. Bergese ; M.D.<sup>esup> ; José ; Marí ; a Eiros ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>gsup> ; Jesú ; s F. Bermejo-Martin ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>fsup> ; José ; I. Gó ; mez-Herreras ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>bsup> ; Eduardo Tamayo ; M.D. ; Ph.D.<sup>asup><sup> ; sup><sup>bsup>
- 关键词：CABG ; coronary artery bypass graft ; PCT ; procalcitonin ; ICU ; intensive care unit ; CPB ; cardiopulmonary bypass ; AKI ; acute kidney injury ; NAKI ; no acute kidney injury ; CRP ; C-reactive protein ; WBC ; white blood cells
- 刊名：Journal of Critical Care
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：233-239
- 全文大小：671 K
sSec_2">Material and Methods
sp0010">A case–control study was designed which included patients that had had cardiac surgery between January 2011 and January 2015. Every patient developing severe sepsis or septic shock (n = 122; 5.5%) was enrolled. In addition, consecutive cardiac surgery patients during 2013 developing systemic inflammatory response syndrome (n = 318) were enrolled. Those recruited 440 patients were divided into 2 groups, according to renal function.
sSec_3">Results
sp0015">Median procalcitonin levels were significantly higher during the 10 postoperative days in the acute kidney injury patients. Regression analysis showed that postoperatory day, creatinine, white blood cells and infection were significantly (P < .0001) associated to serum procalcitonin level. In patients with creatinine ≥ 2, median procalcitonin levels were similar in infected and non-infected patients. Only when creatinine was less than 2 mg/L, the median procalcitonin levels were significantly higher in patients with infection, as compared to those with no infection.
sSec_4">Conclusions
sp0020">In acute kidney injuy patients, high procalcitonin levels are a marker of acute kidney injuy but will not be able to differentiate infected from non-infected patients.