- 作者：Rafael Moreno-Luna ; PhD<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>&lowast ; sup> ; Rocio Muñ ; oz-Hernandez ; BS<sup>2sup><sup> ; sup><sup>&lowast ; sup> ; Ruei-Zeng Lin ; PhD<sup>1sup> ; Maria L. Miranda ; MD ; PhD<sup>2sup> ; Antonio J. Vallejo-Vaz ; MD<sup>2sup> ; Pablo Stiefel ; MD ; PhD<sup>2sup> ; Juan M. Praena-Ferná ; ndez ; BS<sup>3sup> ; José ; Bernal-Bermejo ; BS<sup>4sup> ; Luis M. Jimenez-Jimenez ; MD ; PhD<sup>5sup> ; José ; Villar ; MD ; PhD<sup>2sup> ; Juan M. Melero-Martin ; PhD<sup>1sup><sup> ; sup><sup>juan.meleromartin@childrens.harvard.edu" class="auth_mailsup>
- 关键词：BMI ; Body-mass index ; ECFC ; Endothelial colony-forming cell ; FGF-2 ; Fibroblast growth factor-2 ; VE-cadherin ; Vascular endothelial-cadherin ; VEGF ; Vascular endothelial growth factor
- 刊名：The Journal of Pediatrics
- 出版年：March, 2014
- 年：2014
- 卷：164
- 期：3
- 页码：566-571
- 全文大小：1230 K
ss="h4">Objective
Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that are particularly abundant in umbilical cord blood. We sought to determine whether ECFC abundance in cord blood is associated with maternal body-mass index (BMI) in nonpathologic pregnancies.ss="h4">Study design
We measured the level of ECFCs in the cord blood of neonates (n聽=聽27) born from non-obese healthy mothers with nonpathologic pregnancies and examined whether ECFC abundance correlated with maternal聽BMI. We also examined the effect of maternal BMI on ECFC phenotype and function using angiogenic and vasculogenic assays.
ss="h4">Results
We observed variation in ECFC abundance among subjects and found a positive correlation between prepregnancy maternal BMI and ECFC content (r聽=聽0.51, P聽=聽.007), which was independent of other obstetric factors. Despite this variation, ECFC phenotype and functionality were deemed normal and highly similar between subjects with maternal BMI <25聽kg/m<sup>2sup> and BMI between 25-30聽kg/m<sup>2sup>, including the ability to form vascular networks in聽vivo.
ss="h4">Conclusions
This study underlines the need to consider maternal BMI as a potential confounding factor for cord blood levels of ECFCs in future comparative studies between healthy and pathologic pregnancies.