Synthesis and antimicrobial activities of new higher amino acid Schiff base derivatives of 6-aminopenicillanic acid and 7-aminocephalosporanic acid
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- 作者：Ö ; zlem Ö ; zdemir (nee Gü ; ngö ; r)a ; ozlemgungor@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Perihan Gü ; rkana ; 1 ; pgurkan@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Berrin Ö ; zç ; elikb ; 2 ; berrin@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Ö ; zlem Oyardıb ; 3 ; ozlemyrd@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amino acid Schiff bases ; 6-Aminopenicillanic acid ; 7-Aminocephalosporanic acid ; Antimicrobial activity
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1106
- 期：Complete
- 页码：181-191
- 全文大小：2064 K
文摘
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Novel β-lactam derivatives (1c-3c, 1d-3d) were synthesized by acylating of 6-APA and 7-ACA with the higher amino acid Schiff bases (1b-3b).
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The molecular structures of the β-lactam derivatives were determined by spectroscopic methods.
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Antimicrobial activities of all compounds (1a-3a, 1b-3b, 1c-3c, 1d-3d) were investigated by the broth microdilution method.
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