Plasma pharmacokinetics, bioavailability and tissue distribution of agnuside following peroral and intravenous administration in mice using liquid chromatography tandem mass spectrometry
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- 作者：Rachumallu Ramakrishnaa ; b ; 1 ; Manisha Bhateriaa ; b ; 1 ; Rajbir Singha ; b ; Santosh Kumar Puttrevua ; b ; Rabi Sankar Bhattaa ; b ; rabi.cdri@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Agnuside ; Chaste tree berry ; LC&ndash ; MS/MS ; Pharmacokinetics ; Bioavailability ; Tissue distribution
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：154-164
- 全文大小：1656 K
文摘
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PK and tissue distribution of AGN was assessed by LC–MS/MS for the first time in mice.
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Selective and sensitive method (LLOQ = 1 ng/mL) and requires low sample volume (50 μL).
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Peak AGN concentrations in mouse plasma and tissues were reached within 30–45 min.
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AGN is widely distributed in various tissues, and transfer across blood–brain barrier.
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Tissue distribution: gut > kidney > liver > spleen > brain > lungs > heart.