Tramadol anti-inflammatory activity is not related to a direct inhibitory action on prostaglandin endoperoxide synthases

详细信息    查看全文

• 作者：Carola Buccellati ; Angelo Sala ; Rossana Ballerio ; Mauro Bianchib
• 关键词：tramadol ; prostaglandin endoperoxide synthase-1 ; prostaglandin endoperoxide synthase-2 ; human blood.
• 刊名：European Journal of Pain
• 出版年：2000
• 出版时间：December 2000
• 年：2000
• 卷：4
• 期：4
• 页码：413-415
• 全文大小：74 K

文摘

The analgesic drug tramadol has been shown to relieve pain in inflammatory conditions, to inhibit the development of experimental inflammation, and to reduce prostaglandin (PG)E₂concentrations in the inflammatory exudate. In this study, we evaluated the putative activity of tramadol to suppress prostaglandin endoperoxide synthase-1 (PGHS-1), and prostaglandin endoperoxide synthase-2 (PGHS-2) activities in human whole blood in vitro. Platelet thromboxane (Tx)B₂production and monocyte PGE₂production in LPS- stimulated blood were measured in samples incubated with different concentrations (300 ng/ml, 3 μ g/ml, 30 μ g/ml) of tramadol or its enantiomers. Neither tramadol nor the enantiomers inhibited the formation of arachidonic acid metabolites. Our results indicate that the anti-inflammatory effect of tramadol demonstrated in some models is not related to a direct inhibitory effect on the formation of prostanoids.