Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor
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- 作者：Annie Beuvea ; Changgong Wub ; Chuanlong Cuib ; Tong Liub ; Mohit Raja Jainb ; Can Huanga ; Lin Yanb ; Vladyslav Kholodovychc ; d ; Hong Lib ; liho2@rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asc ; ascorbate ; BCA ; the bicinchoninic acid assay ; BST ; biotin switch technique ; CID ; collision-induced dissociation ; CSNO ; S-nitrosocysteine ; GSNO ; S-nitrosoglutathione ; HCD ; higher-energy collisional dissociation ; MMTS ; methyl methanethiosulfonate ; NCM ; neonatal cardiomyocytes ; PTM ; post-translational modification ; sGC ; soluble guanylyl cyclase ; SMC ; smooth muscle cells
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：14 April 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：40-47
- 全文大小：1459 K
文摘
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Ten mammalian sGC SNO-Cys sites, including nine new ones, were identified in cardiac myocytes.
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The SNO-Cys are conserved, and are mostly solvent-exposed, suggesting functions in protein-protein interactions.