Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2

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• 作者：Tao Jiang ; Kelli L. Kuhen ; Karen Wolff ; Hong Yin ; Kimberly Bieza ; Jeremy Caldwell ; Badry Bursulaya ; Tove Tuntland ; Kanyin Zhang ; Donald Karanewsky and Yun He
• 关键词：AIDS ; HIV ; Reverse transcriptase ; Inhibitor ; Oxindole ; Heterocycle ; SAR
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 April 2006
• 年：2006
• 卷：16
• 期：8
• 页码：2109-2112
• 全文大小：155 K

文摘

A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.