Development of predictive models for predicting binding affinity of endocrine disrupting chemicals to fish sex hormone-binding globulin

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• 作者：Huihui Liu^a ; ^{hhliu@njust.edu.cn} ; Xianhai Yang^b ; ^{xhyang@nies.org} ; Cen Yin^a ; Mengbi Wei^a ; Xiao He^a
• 关键词：Endocrine disrupting chemicals (EDCs) ; Fish sex hormone-binding globulin (fSHBG) ; Quantitative structure-activity relationship (QSAR) ; Classification model ; Relative binding affinity (RBA)
• 刊名：Ecotoxicology and Environmental Safety
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：46-54
• 全文大小：734 K
• 卷排序：136

文摘

An important pathway for EDCs exerting disrupting endocrine function was emphasized. Classification and QSAR models were developed for predicting the binding affinity. A good relationship of binding data occurred within fish species in the same Order.