PTSD is associated with glucocorticoid (GC) receptor (GR) and FKBP5 alterations.

However, their interplay and role in endocrine-immune signaling in PTSD is unclear.

High GC-sensitive PTSD patients showed a linked expression of GRα and FKBP5.

This suggests a physiological adaptation preserving immune-relevant GC signaling.

GRα-FKBP5 de-synchronization was observed in low GC-sensitive PTSD patients.

This may indicate unraveling endocrine-immune communication or a transition stage.