Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP)
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- 作者：Cheol Kyu Hwang ; Yadav Wagley ; ywagley@umn.edu ; Ping-Yee Law ; Li-Na Wei ; Horace H. Loh
- 关键词：PCBP1 ; poly(rC) binding protein 1 ; MOR ; mu opioid receptor ; AUF1 ; AU-rich element RNA-binding protein 1 ; PABP ; poly (A)-binding protein ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; PKA ; protein kinase A ; PKC ; protein kinase C ; CRE ; C-rich element ; RNA-EMSA ; RNA electrophoretic mobility shift assay ; ARE ; AU-rich elements ; hnRNPs ; heterogeneous nuclear ribonucleoproteins ; HuR ; human antigen R ; RNPs ; ribonucleoproteins ; ILEI ; interleukin-like EMT inducer ; Dab2 ; disabled-2 ; STR ; short tandem repeats
- 刊名：Gene
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：598
- 期：Complete
- 页码：113-130
- 全文大小：1710 K
- 卷排序：598
文摘
PCBP1 binds to a novel C-rich element in the MOR 3′-UTR. PKA activation increases the serine 246 phosphorylation of PCBP1. PCBP1 forms a ribonucleoprotein complex with AUF1 and PABP. Knockdown of PCBP1 decreases MOR mRNA stability.