Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry
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- 作者：Tin-Long Wonga ; 1 ; Ya-Qi Anb ; 1 ; Bing-Chao Yanb ; Rui-Qi Yuea ; Tian-Bo Zhanga ; Hing-Man Hoa ; Tian-Jing Rena ; Hau-Yee Funga ; Dik-Lung Mac ; Chung-Hang Leungd ; Zhong-Liang Liue ; Jian-Xin Pub ; pujianxin@mail.kib.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Quan-Bin Hana ; simonhan@hkbu.edu.hk" class="auth_mail" title="E-mail the corresponding author ; Han-Dong Sunb
- 关键词：YinHuang drop pill ; Chinese medicine formulas ; Quantitative analysis ; Quality evaluation
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：415-426
- 全文大小：1970 K
文摘
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Up to 73% (w/w) of commercial YinHuang drop pill (YHDP) was quantitatively analyzed.
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Twenty-six small molecules were determined using UHPLC-Q-TOF-MS.
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One excipient (PEG4000) was determined using UHPLC-CAD.
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Carbohydrates were examined using HPGPC and HPLC-NH2P-ELSD.
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The chemical profile of YHDP was quantitatively compared with other YinHuang preparations.