The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: A potential for drug delivery system
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- 作者：Bing-Mi Liu ; liubingmi@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Zhang ; Ai-Jun Hao ; Liang Xu ; Dan Wang ; Hui Ji ; Shi-Jie Sun ; Bo-Qi Chen ; Bin Liu ; liubinzehao@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rutin ; Baicalin ; Curcumin ; Human serum albumin ; Interaction ; Drug delivery
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：88-94
- 全文大小：859 K
文摘
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The effects of rutin and baicalin on the interaction of curcumin with HSA were studied.
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The fluorescence quenching of HSA by curcumin is a combined quenching process.
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Flavonoids had no influence on the combined quenching mechanism.
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The binding affinity of curcumin with HSA was increased in the presence of flavonoids.
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Rutin/bacalin and curcumin may simultaneously bind in different regions of site I.