Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

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• 作者：Laurent Legentil^a ; Sorya Belaz^b ; ^c ; Jean-Pierre Gangneux^b ; ^c ; Florence Robert-Gangneux^b ; ^c ; ¹ ; Vincent Ferriè ; res^a ; ¹ ; ^{vincent.ferrieres@ensc-rennes.fr}
• 关键词：Carbohydrates ; Galactofuranosides ; Fluorescence ; Leishmania ; Macrophages
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：27
• 期：2
• 页码：152-155
• 全文大小：697 K
• 卷排序：27

文摘

Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.