Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

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• 作者：Tore Skotland^a ; ^b ; Kim Ekroos^c ; Dimple Kauhanen^c ; Helena Simolin^c ; Therese Seierstad^d ; Viktor Berge^e ; Kirsten Sandvig^a ; ^b ; ^f ; Alicia Llorente^a ; ^b ; ^{Alicia.Martinez.Llorente@rr-research.no}
• 关键词：Diagnostics ; Exosomes ; Extracellular vesicles ; High-throughput quantitative lipidomics ; Lipids ; Liquid biopsy ; Non-invasive biomarkers ; Prostate cancer ; Urine
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：70
• 期：Complete
• 页码：122-132
• 全文大小：1060 K
• 卷排序：70

文摘

Urinary exosomal lipids are a new source of non-invasive prostate cancer biomarkers. Combinations of three lipid species have a high diagnostic capacity for prostate cancer. The study reveals for the first time the lipidome of urinary exosomes in detail.