Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells
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- 作者：Mengling Liu1 ; 9 ; Yingfeng Xia1 ; 9 ; Jane Ding2 ; 9 ; Bingwei Ye2 ; Erhu Zhao8 ; Jeong-Hyeon Choi2 ; 3 ; Ahmet Alptekin2 ; 4 ; Chunhong Yan2 ; 4 ; Zheng Dong2 ; 5 ; Shuang Huang7 ; Liqun Yang8 ; Hongjuan Cui8 ; Yunhong Zha1 ; yzha7808@ctgu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Han-Fei Ding2 ; 4 ; 6 ; 10 ; hding@augusta.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer metabolism ; cholesterol biosynthesis ; high-risk neuroblastoma ; mevalonate pathway ; MYCN ; neuroblastoma stem cells ; serine-glycine biosynthesis ; statin ; TH-MYCN mouse
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：609-623
- 全文大小：6045 K
文摘
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TH-MYCN mouse neuroblastoma sphere-forming cells are cancer stem-like cells
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Their function requires activation of serine and cholesterol synthesis pathways
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These metabolic pathway genes are activated in high-risk human neuroblastoma
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Metabolic gene expression may be prognostic for neuroblastoma patients
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