Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

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• 作者：Alexander Mischnik^a ; ^b ; ^{alexander.mischnik@uniklinik-freiburg.de} ; Philipp Baumert^a ; ^b ; Axel Hamprecht^a ; ^c ; Anna Rohde^a ; ^d ; Silke Peter^a ; ^e ; Susanne Feihl^a ; ^f ; Johannes Knobloch^a ; ^g ; ^h ; Hanna Gö ; lz^a ; ⁱ ; Axel Kola^a ; ^d ; Birgit Obermann^a ; ^g ; Christiane Querbach^a ; ^f ; Matthias Willmann^a ; ^e ; Friedemann Gebhardt^a ; ^f ; Evelina Tacconelli^a ; ^j ; Petra Gastmeier^a ; ^d ; Harald Seifert^a ; ^c ; Winfried V. Kern^a ; ^b ; on behalf of the DZIF-ATHOS Study Group¹
• 关键词：Extended-spectrum β-lactamase ; β-Lactamase inhibitor ; AmpC
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：1
• 页码：71-73
• 全文大小：347 K
• 卷排序：87

文摘

Three hundred twenty-eight E. coli, 35 Klebsiella spp., (1 K. oxytoca and 34 K. pneumoniae) and 16 Enterobacter spp. (1 E. aerogenes and 15 E. cloacae) well-characterized isolates nonsusceptible to third-generation cephalosporins were tested by broth microdilution antimicrobial susceptibility testing. The following concentration ranges were included: ampicillin/sulbactam (2/4–16/4 mg/L), amoxicillin/clavulanic acid (4/2–32/2 mg/L), piperacillin/tazobactam (1/4–128/4 mg/L), mecillinam (0.5–64 mg/L), mecillinam/clavulanic acid (0.5/4–64/4 mg/L), and temocillin (1–128 mg/L). Our study gives insight in β-lactam MIC distributions of a collection of well-characterized German 3GCREB isolates. Several β-lactam antibiotics showed good in vitro activity and may serve as treatment options for infections.