New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives

详细信息    查看全文

• 作者：Marí ; a A. Ramí ; rez^a ; Marí ; a V. Corona^a ; Gisela Ortiz^a ; Alejandra Salerno^a ; Isabel A. Perillo^a ; Marí ; a M. Blanco ; ^a ; ^{mblanco@ffyb.uba.ar} ; ^{mercedesblanco2@yahoo.com.ar}
• 关键词：1 ; n-Diamines ; Selectively substituted tetra(penta)methylenediamines ; Azidoamides ; Microwave irradiation ; Diborane reductions
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：30 March 2011
• 年：2011
• 卷：52
• 期：13
• 页码：1466-1468
• 全文大小：218 K

文摘

A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.