Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema

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• 作者：Michael Hawkes ; Ian Kitai ; Susan Blaser ; Eyal Cohen ; Ari Bitnun ; Joel Fluss ; Dat Tran
• 关键词：Isoniazid toxicity ; Intramyelinic edema ; Slow acetylator ; Medication error
• 刊名：European Journal of Paediatric Neurology
• 出版年：2008
• 出版时间：November 2008
• 年：2008
• 卷：12
• 期：6
• 页码：512-515
• 全文大小：300 K

文摘

We describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. We postulate that these imaging findings were the result of intramyelinic edema, previously described in experimental animal models of isoniazid toxicity.