The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss

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• 作者：Zi Xu^a ; ^b ; ¹ ; Weijia Sun^a ; ^b ; ¹ ; Yuheng Li^b ; ¹ ; Shukuan Ling^b ; Chenyang Zhao^a ; ^b ; ² ; Guohui Zhong^b ; Dingsheng Zhao^b ; Jinping Song^b ; Hailin Song^a ; Jinqiao Li^b ; Linhao You^a ; Guangjun Nie^c ; Yanzhong Chang^a ; ^{chang7676@163.com} ; Yingxian Li^b ; ^{yingxianli@aliyun.com}
• 关键词：DFO ; chelator deferoxamine mesylate ; TfR1 ; transferrin receptor 1 ; DMT1  ; +  ; IRE ; divalent metal transporter 1 with iron response element ; FPN1 ; iron transporter ferroportin 1 ; BMP6 ; Bone morphogenetic protein 6 ; BMD ; bone mineral density ; microCT ; micro computed tomography ; HS ; hindlimb suspension ; BV/TV ; ratio of bone volume to tissue volume ; bone volume/total bone volume ; Tb.Sp ; trabecular separation
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：152-161
• 全文大小：1586 K
• 卷排序：94

文摘

Iron over-deposition contributes to unloading induced bone loss. Iron overload is coupled with the over-expression of hepcidin by the liver. Inhibition of hepcidin up-regulation aggravates hindlimb unloading-induced bone loss.