DNA double-strand breaks in meiosis: Checking their formation, processing and repair

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• 作者：Maria Pia Longhese ; Diego Bonetti ; Ilaria Guerini ; Nicola Manfrini ; Michela Clerici
• 关键词：Double-strand breaks ; Meiosis ; Checkpoint ; CDK ; Mek1 ; Rad53
• 刊名：DNA Repair
• 出版年：2009
• 出版时间：2 September 2009
• 年：2009
• 卷：8
• 期：9
• 页码：1127-1138
• 全文大小：1150 K

文摘

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minimize the risk of deleterious effects, meiotic DSB formation, processing and repair are tightly regulated in order to occur only at the right time and place. Furthermore, a highly conserved signal-transduction pathway, called meiotic recombination checkpoint, coordinates DSB repair with meiotic progression and promotes meiotic recombination.