A flexible synthesis of novel homoharringtonine ester chain

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• 作者：Thi Hong Nhung Nguyen^a ; Thai Thanh Thu Bui^a ; Phong Van Pham^b ; Dinh Hung Mac^a ; ^{macdinhhung@vnu.edu.vn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mizoroki&ndash ; Heck reaction ; Boronic acids ; Homoharringtonine ; d-Malic acid
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：13 January 2016
• 年：2016
• 卷：57
• 期：2
• 页码：216-218
• 全文大小：1598 K

文摘

New homoharringtonine ester chains bearing aryl substituents were obtained using a flexible synthesis. d-Malic acid was utilized to achieve the diastereoselective allylation at the C2′ center. A key oxidative Mizoroki–Heck reaction allowed the coupling of various phenyl boronic acids with the allyl intermediate to provide arylated products in excellent yields.