Ionic liquid-based solid phase microextraction necklaces for the environmental monitoring of ketamine

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• 作者：Federica Bianchi ; Franco Bisceglie ; Stefano Dugheri ; Giulio Arcangeli ; Vincenzo Cupelli ; Elia del Borrello ; Len Sidisky ; Maria Careri
• 关键词：Ketamine ; Environmental monitoring ; Personal device ; Portable device ; Ionic liquids ; Rapid SPME
• 刊名：Journal of Chromatography A
• 出版年：28 February, 2014
• 年：2014
• 卷：1331
• 期：Complete
• 页码：1-9
• 全文大小：1553 K

文摘

Wearable solid phase microextraction (SPME) devices consisting in necklaces and pins were developed for the environmental monitoring of ketamine in recreational places using ionic liquid as coating. SPME fibers obtained using both monocationic and dicationic polymeric ionic liquids were characterized in terms of morphology, film thickness, thermal stability and pH resistance. An average thickness of 30 卤 5 渭m, an excellent thermal stability until 350 掳C and a very good fiber-to-fiber and batch-to-batch repeatability with RSD lower than 4% were some of the features of the developed coatings. A quantitation limit (LOQ) of 0.05 mg/m³ with a sampling time of 1 min proved the feasibility of the developed method for the quantitation of ketamine in air at low concentration levels. Finally, the capabilities of the fibers for the rapid SPME sampling of ketamine in recreational places were proved obtaining extraction efficiencies at least two-fold higher than those obtained using commercial devices and extraction recoveries ranging from 84.2 卤 3.3% to 93.6 卤 2.6% (n = 3).