Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes

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• 作者：Valé ; rie Siroux ; PhD^a ; ^b ; ^c ; ^{Valerie.siroux@ujf-grenoble.fr" class="auth_mail" title="E-mail the corresponding author} ; Anne Boudier ; MSc^a ; ^b ; ^c ; Maï ; a Dolgopoloff ; MSc^a ; ^b ; ^c ; Sé ; bastien Chanoine ; PharmD^a ; ^b ; ^c ; Jean Bousquet ; MD ; PhD^d ; ^e ; ^f ; Frederic Gormand ; MD^g ; Jocelyne Just ; MD^h ; ⁱ ; Nicole Le Moual ; PhD^d ; ^e ; Rachel Nadif ; PhD^d ; ^e ; Christophe Pison ; MD ; PhD^j ; ^k ; ^l ; Raphaë ; lle Varraso ; PhD^d ; ^e ; Regis Matran ; MD^m ; Isabelle Pin ; MD^a ; ^b ; ^c
• 关键词：Asthma ; small airways ; FEF25-75 ; epidemiology ; longitudinal
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：137
• 期：6
• 页码：1709-1716.e6
• 全文大小：915 K

文摘

Whether small-airway obstruction contributes to the long-term evolution of asthma remains unknown.

Objectives

Our aim was to assess whether the level of forced midexpiratory flow between 25% and 75% of forced vital capacity (FEF_25-75) was associated with the persistence of current asthma over 20 years and the subsequent risk for uncontrolled asthma independently of FEV₁.

Methods

We studied 337 participants (142 children and 225 adults) with current asthma (asthma attacks or treatment in the past 12 months) recruited to the Epidemiological Study on the Genetics and Environment of Asthma (EGEA1) and followed up at the 12- and 20-year surveys. Persistent current asthma was defined by current asthma reported at each survey. A lung function test and a methacholine challenge test were performed at EGEA1 and EGEA2. Adjusted odds ratios (ORs) were estimated for FEF_25-75 decreased by 10% of predicted value.

Results

A reduced level of FEF_25-75 at EGEA1 increased the risk of long-term asthma persistence (adjusted OR, 1.14; 95% CI, 1.00-1.29). In children the association remained significant after further adjustment for FEV₁ and in participants with FEV₁ of greater than 80% of predicted value. A reduced FEF_25-75 level at EGEA1 was significantly associated with more severe bronchial hyperresponsiveness (P < .0001) and with current asthma a decade later, with an association that tended to be stronger in those with (adjusted OR, 1.44; 95% CI, 1.14-1.81) compared with those without (adjusted OR, 1.21; 95% CI, 1.05-1.41) asthma exacerbation.

Conclusion

Our analysis is the first to suggest that small-airway obstruction, as assessed based on FEF_25-75, might contribute to the long-term persistence of asthma and the subsequent risk for poor asthma outcomes independently from effects of the large airways.