Rectal contrast increases rectal dose during vaginal cuff brachytherapy

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• 作者：Sebastia Sabater¹ ; ^{ssabaterm@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ignacio Andres¹ ; Esther Jimenez-Jimenez² ; Roberto Berenguer¹ ; Marimar Sevillano¹ ; Veronica Lopez-Honrubia¹ ; Angeles Rovirosa³ ; Ricardo Sanchez-Prieto⁴ ; ⁵ ; Meritxell Arenas⁶
• 关键词：Endometrial cancer ; Vaginal cuff brachytherapy ; Rectal contrast ; Dose-volume histogram
• 刊名：Brachytherapy
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：15
• 期：1
• 页码：35-39
• 全文大小：540 K

文摘

To evaluate the impact of rectal dose on rectal contrast use during vaginal cuff brachytherapy (VCB).

Methods and Materials

A retrospective review of gynecology patients who received some brachytherapy fractions with and without rectal contrast was carried out. Rectal contrast was instilled at the clinician's discretion to increase rectal visibility. Thirty-six pairs of CT scans in preparation for brachytherapy were analyzed. Pairs of CTs were segmented and planned using the same parameters. The rectum was always defined from 1 cm above the cylinder tip up to 1.5 cm below the last activated dwell source position. An individual plan was computed at every VCB fraction. A set of values (D_max, D_0.1cc, D_1cc, and D_2cc) derived from dose-volume histograms were extracted and compared according to the rectal status.

Results

Rectal volume was 26.7% larger in the fractions with rectal contrast. Such an increase in volume represented a significant increase from 7.7% to 10.4% in all parameters analyzed except D_max dose-volume histogram.

Conclusions

Avoiding rectal contrast is a simple way of decreasing the rectal dose parameters of VCB, which would mean a better therapeutic ratio. Results also suggest that action directed at maintaining the rectum empty might have the same effect.