Human fetal intestinal epithelial cells metabolize and incorporate branched chain fatty acids in a structure specific manner

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• 作者：Lei Liu^a ; ^b ; Zhen Wang^b ; Hui Gyu Park^b ; Chuang Xu^b ; ^c ; Peter Lawrence^b ; Xueli Su^b ; ^d ; Vasuki Wijendran^e ; ¹ ; W. Allan Walker^e ; Kumar S.D. Kothapalli^b ; ^{ksk25@cornell.edu} ; J. Thomas Brenna^b ; ^{jtb4@cornell.edu}
• 关键词：BCFA ; (branched-chain fatty acids) ; CE ; (cholesterol esters) ; DAG ; (diacylglycerol) ; FAME ; (fatty acid methyl esters) ; GI ; (gastrointestinal) ; MAG ; (monoacylglycerol) ; NEC ; (necrotizing enterocolitis) ; PL ; (phospholipids) ; SFA ; (saturated fatty acids) ; TAG ; ( triacylglycerol)
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：32-39
• 全文大小：878 K
• 卷排序：116

文摘

Human fetuses among terrestrial animals are uniquely exposed to vernix caseosa rich in BCFA. Human fetal enterocytes (H4) incubated with BCFA incorporate them into membrane phospholipids. BCFA displaced 16:0 and 18:0 in preference to mono and polyunsaturates. Normal H4 incorporate high levels of BCFA in vivo when exposed to vernix in late gestation.