Behavioral and electromyographic assessment of oxaliplatin-induced motor dysfunctions: Evidence for a therapeutic effect of allopregnanolone

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• 作者：O. Taleb¹ ; ; F. Bouzobra¹ ; H. Tekin-Pala ; L. Meyer ; A.G. Mensah-Nyagan² ; C. Patte-Mensah² ; ^{cmensah@unistra.fr}
• 关键词：Motor disorders ; Nerve fiber dysfunction ; Neuroprotection ; Neurosteroid ; Peripheral neuropathy
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：440-449
• 全文大小：1756 K
• 卷排序：320

文摘

We validated a rat model of oxaliplatin-evoked motor neuropathy. Wire suspension and balance beam tests showed motor deficit in OXAL-treated rats. Motor fiber conductance velocity was reduced in OXAL-treated rats. OXAL-treatment increased the compound muscle action potential duration. Allopregnanolone treatment successfully corrected OXAL-evoked motor dysfunctions.