The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis
详细信息 查看全文
- 作者：Callie A.S. Corsa1 ; 2 ; 3 ; Audrey Brenot1 ; 3 ; Whitney R. Grither1 ; 3 ; 4 ; Samantha Van Hove1 ; 2 ; 3 ; Andrew J. Loza1 ; 3 ; 5 ; Kun Zhang1 ; 3 ; Suzanne M. Ponik6 ; Yuming Liu7 ; David G. DeNardo1 ; 3 ; Kevin W. Eliceiri7 ; Patricia J. Keely6 ; 7 ; Gregory D. Longmore1 ; 2 ; 3 ; glongmore@wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：15
- 期：11
- 页码：2510-2523
- 全文大小：3712 K
文摘
- •
DDR2 activity in both tumor and stromal cells is critical for breast cancer metastasis
- •
DDR2 regulates collective invasion/migration of basal K14+ breast tumor cells
- •
In CAFs, DDR2 regulates tumor ECM production and collagen fiber remodeling
- •
In CAFs, DDR2 enhances tumor collective invasion/migration