Abnormal auditory pattern perception in schizophrenia
详细信息 查看全文
- 作者：Sarah M. Haigh ; haighsm@upmc.edu" class="auth_mail" title="E-mail the corresponding author ; ; Brian A. Coffman ; Timothy K. Murphy ; Christiana D. Butera ; Dean F. Salisbury
- 关键词：Mismatch negativity ; Schizophrenia ; Complex-pattern deviant ; Perceptual grouping
- 刊名：Schizophrenia Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：176
- 期：2-3
- 页码：473-479
- 全文大小：1063 K
文摘
Mismatch negativity (MMN) in response to deviation from physical sound parameters (e.g., pitch, duration) is reduced in individuals with long-term schizophrenia (Sz), suggesting deficits in deviance detection. However, MMN can appear at several time intervals as part of deviance detection. Understanding which part of the processing stream is abnormal in Sz is crucial for understanding MMN pathophysiology. We measured MMN to complex pattern deviants, which have been shown to produce multiple MMNs in healthy controls (HC). Both simple and complex MMNs were recorded from 27 Sz and 27 matched HC. For simple MMN, pitch- and duration-deviants were presented among frequent standard tones. For complex MMN, patterns of five single tones were repeatedly presented, with the occasional deviant group of tones containing an extra sixth tone. Sz showed smaller pitch MMN (p = 0.009, ~ 110 ms) and duration MMN (p = 0.030, ~ 170 ms) than healthy controls. For complex MMN, there were two deviance-related negativities. The first (~ 150 ms) was not significantly different between HC and SZ. The second was significantly reduced in Sz (p = 0.011, ~ 400 ms). The topography of the late complex MMN was consistent with generators in anterior temporal cortex. Worse late MMN in Sz was associated with increased emotional withdrawal, poor attention, lack of spontaneity/conversation, and increased preoccupation. Late MMN blunting in schizophrenia suggests a deficit in later stages of deviance processing. Correlations with negative symptoms measures are preliminary, but suggest that abnormal complex auditory perceptual processes may compound higher-order cognitive and social deficits in the disorder.