Androgen biosynthesis during minipuberty favors the backdoor pathway over the classic pathway: Insights into enzyme activities and steroid fluxes in healthy infants during the first year of life from the urinary steroid metabolome

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• 作者：Nasser A. Dhayat^a ; ^{nasser.dhayat@insel.ch} ; Bernhard Dick^a ; ^{bernhard.dick@insel.ch} ; Brigitte M. Frey^a ; ^{brigitte.frey@dkf.unibe.ch} ; Claudia H. d&rsquo ; Uscio^a ; ^{claudia.d'uscio@insel.ch} ; Bruno Vogt^a ; ^{bruno.vogt@insel.ch} ; Christa E. Flü ; ck^b ; ^{christa.flueck@dkf.unibe.ch} ; ^{christa.flueck@insel.ch}
• 关键词：Newborn infants ; GC&ndash ; MS ; Urinary steroid profile ; Urinary steroid metabolome ; Minipuberty ; Androgens ; Steroid enzyme activity ; Development
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：312-322
• 全文大小：1086 K
• 卷排序：165

文摘

Male androgen biosynthesis shows a significant peak at week 7 during minipuberty. Androgens in minipuberty are (at least in part) produced through the backdoor pathway. Steroid enzyme activities in the first year of life are all age-, some sex-specific. Steroid enzyme ratios obtained from urine GC–MS are comparable between laboratories.